• Efficacy of amoxicillin is dependent on the amount of time the drug concentration exceeds the minimum inhibitory concentration of the target pathogen3
• Timed releases of amoxicillin from MOXATAG ensure adequate drug levels to treat S.pyogenes with just 1 daily dose for 10 days1
• The tablet disintegrates rapidly in the stomach, releasing 3 components: an immediate-release granule that dissolves rapidly (pulse 1) and 2 delayed-release components that release amoxicillin in different regions of the intestinal tract (pulses 2 and 3)4
References: 1. MOXATAG [package insert]. Berwyn, PA: Vernalis Therapeutics, Inc; 2016. 2. Orange Book: Approved drug products with therapeutic equivalence evaluations. US Food and Drug Administration website. http://www.accessdata.fda.gov/scripts/cder/ob/search_product.cfm. Accessed August 2, 2017. 3. Turnidge JD. The pharmacodynamics of beta-lactams. Clin Infect Dis. 1998;27(1):10-22. 4. Robertson SM, Bonapace C. Center for Drug Evaluation and Research. Application Number: 50-813. Clinical Pharmacology and Biopharmaceutics Review(s). http://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/050813s000clinpharmr.pdf. Accessed August 4, 2017.